Processes and Applications

Processes and Applications

Process development is a key element in the creation of improved, more rapid and lower-cost methods for producing target products. Every strain or cell line exhibits a different behavior, meaning growth properties, nutritional requirements and expression levels can deviate significantly. Through evaluating feeding strategies, pH value optimization, and process automation, process engineers can optimize growth, stability, and productivity levels.
Here, we show how applying appropriate methods for reliable scaling can support the economical and efficient development of biotechnological products. We discuss different feeding principles and highlight the advantages and limitations of perfusion cultivation. Finally, we take a closer look at stem cell cultivation and explain how stem cell scientists can benefit from cultivating their cells in bioreactors.

Stem Cell Cultivation in Bioreactors: Increasing hiPSC Yield

Robert Zweigerdt from Hannover Medical School explains, how his team greatly increased the hiPSC yield in bioreactors.

Bioprocess Development for Biosimilar Production

Establishing robust upstream bioprocesses and scaling them up to larger volumes are critical steps in biosimilar development. We have talked with...

Beaker or Swimming Pool: Why Microbes Dislike big Vessels

Biotechnological production processes use microbes with exceptional capabilities. Among others, they originate from soil, digestive system, plant...

It’s Not Just About Size: Talking about Shake Flasks and Bioreactors

Shake flasks and bioreactors are both important tools for bioprocessing, but are very different in many respects. Bioreactors clearly offer a much...

Stem Cells: Promising Opportunities but Highest Demands

Stem cells are expected to be among the most powerful medicines of the future. They have considerable potential for novel cell-based therapies, tissue...

Perfusion – Making the Most out of Your Working Volume

Bioprocessing of eukaryotic cells and microorganisms is used in the production of a wide range of goods, including biopharmaceuticals for diagnostic...

It’s a Matter of Volume: Bioprocess Scalability

Regardless what kind of production process a bioreactor or fermentor is used for, efficiencies of time and cost are major factors to consider....